In this YouTube video entitled "Accepting No as an Answer", the speaker explores 2nd Corinthians chapter 12 verses 1 through 10 where the Apostle Paul talks about his thorn in the flesh. The video discusses how Paul prayed enough to accept "no" as an answer and how we should trust God to answer our prayers according to His will.

The speaker emphasizes the importance of praying, trusting God, and seeking medical attention when we are sick. The video also highlights the earnest and persistent way that Paul prayed, even though God's answer was not what he expected. Ultimately, the video aims to remind viewers that God answers prayer, but according to His own will, not ours.