In this episode, we dive into the latest updates on medications used in Advanced Cardiovascular Life Support (ACLS), focusing on epinephrine, amiodarone, lidocaine, vasopressin, and esmolol. We also discuss the VSE protocol (vasopressin, steroids, and epinephrine), highlighting its potential to improve ROSC outcomes. Additionally, we review changes in timing, dosing, and clinical indications, along with post-cardiac arrest medication management strategies.