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Activation Mechanisms for Context-Dependent Allosteric Modulation of the mGlu7 receptor
The Promise of Discovery Season 4, Episode 4
This research examines mGlu7, a transmembrane receptor involved in several neurodevelopmental disorders, such as Rett syndrome, ADHD, schizophrenia, and Neurofibromatosis Type 1. The project discussed studies the mechanism of mGlu7 activation by allosteric modulators to develop new treatments and help guide drug discovery efforts.
Featuring: Xia Lei, Ph.D., postdoctoral fellow, Vanderbilt University
Interviewer: Colleen Niswender, Ph.D., associate professor of Pharmacology; Director of Molecular Pharmacology, Warren Center for Neuroscience Drug Discovery; and a Vanderbilt Kennedy Center Member
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By Vanderbilt Kennedy Center
5
33 ratings
The Promise of Discovery Season 4, Episode 4
This research examines mGlu7, a transmembrane receptor involved in several neurodevelopmental disorders, such as Rett syndrome, ADHD, schizophrenia, and Neurofibromatosis Type 1. The project discussed studies the mechanism of mGlu7 activation by allosteric modulators to develop new treatments and help guide drug discovery efforts.
Featuring: Xia Lei, Ph.D., postdoctoral fellow, Vanderbilt University
Interviewer: Colleen Niswender, Ph.D., associate professor of Pharmacology; Director of Molecular Pharmacology, Warren Center for Neuroscience Drug Discovery; and a Vanderbilt Kennedy Center Member
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