In this episode, we explore evidence-based pharmacological treatments for severe gastrointestinal bleeding, drawing from Cochrane systematic reviews. Topics include the use of antibiotic prophylaxis in cirrhotic patients to prevent infections and reduce mortality, the impact of proton pump inhibitors (PPIs) started before endoscopy on patient outcomes, and the effectiveness of somatostatin analogues for managing acute bleeding from esophageal varices. Join us for a deep dive into strategies that improve care and outcomes in upper gastrointestinal hemorrhage.