This podcast contains multiple Patient Group Directions (PGDs) authorized by the NHS England Pharmacy First service, outlining the conditions and protocols for pharmacists to supply specific medications for acute sinusitis. The documents systematically detail the use of two nasal steroid sprays, Fluticasone and Mometasone, for general acute sinusitis in individuals aged twelve and over, and three oral antibiotics, Clarithromycin, Doxycycline, and Erythromycin, reserved for cases of suspected acute bacterial sinusitis when a penicillin allergy is present. Crucially, each PGD establishes precise inclusion and exclusion criteria, such as minimum age, symptom duration, signs of bacterial infection, and contraindications related to immunosuppression or concurrent drug use, ensuring safe supply under specific medical and regulatory guidelines. The documentation, which is peer-reviewed and officially dated, also provides essential information on dosage, storage, potential adverse reactions, patient counseling, and detailed referral pathways for serious complications or exclusions.