Dr. Brian Grahan is an internal medicine and addiction medicine physician at Hennepin Healthcare. In this episode, he walks us through the realities of addiction medicine, including what it’s like to be a patient in a clinic, options for medications for opioid use disorder, and how care is structured. He focuses on the profound brain changes that occur in opioid use disorder—and how these changes affect decision-making, motivation, and the ability to engage in care. Dr. Grahan also shares why he sees EMS as a critical partner in initiating buprenorphine and expanding access to evidence-based treatment where and when patients need it most.