In this episode of Neuro-vascular Edge: MENA-SINO's Pre-Conference Pulse, we explore a critical study on the 'no-reflow' phenomenon that affects stroke patients post-thrombectomy. Despite successful blood clot removal, many patients experience inadequate blood flow to brain tissue, leading to poor outcomes. We discuss key findings from the extensive research analyzing over 450 patients, uncovering the substantial impact of microvascular health on clinical results. This dialogue emphasizes the importance of ensuring tissue-level reperfusion alongside vessel recanalization to improve patient care and therapeutic strategies.