Addressing Penicillin Allergies in Primary Care - Frankly Speaking Ep 356

Credits: 0.25 AMA PRA Category 1 Credit™ CME/CE Information and Claim Credit: https://www.pri-med.com/online-education/podcast/frankly-speaking-cme-356

Overview: Patient-reported penicillin allergies are common; however, more than 95% of such patients have negative penicillin allergy testing and will tolerate subsequent antibiotic use. Currently, disproving a penicillin allergy includes negative skin testing followed by an oral challenge, which is considered the gold standard to remove the penicillin allergy label, as skin testing alone lacks 100% negative predictive value. Recent reports have suggested that low-risk individuals can be assessed with a direct oral challenge, but the safety and efficacy of such an approach has not been rigorously studied. Listen in as expert faculty discuss a recent randomized controlled trial that validates such an approach.

Episode resource links:

Trubiano JA, Vogrin S, Chua KYL et al. Development and Validation of a Penicillin Allergy Clinical Decision Rule. JAMA Internal Med. Published March 16, 2020. doi:10.1001/jamainternmed.2020.0403

JAMA Intern Med. doi:10.1001/jamainternmed.2023.2986

Guest: Robert A. Baldor MD, FAAFP Music Credit: Richard Onorato