February 28, 2022

ADHD and maternal substance use with Elis Haan

17 minutes

Dr Elis Haan talks to Dr Rob Calder about ADHD and maternal substance use. She discusses her recent paper which explored the impact of smoking, alcohol and drugs during pregnancy on ADHD outcomes in young people.

Elis talks about the differences between maternal and teacher ratings of ADHD. She also explains negative control and polygenic risk score methods used in this study discussing how multiple methods were used across different longitudinal datasets to add confidence to their analysis.

“Combining these different methods can help to gain stronger support for a causal effect…. For example, if these different methods and analyses across these cohorts provide similar results we can be more confident that the results reflect a true causal effect. This is because it is unlikely that these different methods will be all biased in the same way”

Haan E, Sallis HM, Zuccolo L,Labrecque J, Ystrom E, Reichborn-Kjennerud T, et al. Prenatal smoking, alcohol and caffeine exposure and maternal-reported attention deficit hyperactivity disorder symptoms in childhood: triangulation of evidence using negative control and polygenic risk score analyses. Addiction. 2021;1–14. https://doi.org/10.1111/add.15746.

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