In this episode, we focus on Advanced Trauma Life Support (ATLS) principles, with a special emphasis on the role of tranexamic acid (TXA) in trauma care. We review key clinical trials, including CRASH-2 and CRASH-3, discussing their findings, methodologies, and ongoing debates about TXA’s efficacy and safety in major trauma and traumatic brain injury. Additionally, we cover important trauma management topics such as the use of intravenous calcium during massive transfusions and the strategy of permissive hypotension.