The value of Magnetoencephalography (MEG) in detecting and localizing focal interictal epileptiform discharges (IEDs) in epilepsy patients is undisputed. However, current cryogenic MEG systems present limitations, particularly for pediatric patients, due to their rigid helmet design. In this episode, we discuss these challenges and potential solutions with Dr. Feys, whose research focuses on on-scalp MEG technology using optically pumped magnetometers (OPMs).

Dr. Feys' team conducted a single-center study on school-aged children with either self-limited idiopathic or refractory focal epilepsy. The researchers compared IED detection and localization using traditional cryogenic MEG and the new on-scalp MEG method. Their results showed that the on-scalp MEG provided higher IED amplitudes, a better signal-to-noise ratio, and similar localization value, even with a limited number of sensors and scalp coverage.

Despite occasional motion artifacts from head movements, this pioneering study suggests that on-scalp MEG could alleviate the main limitations of cryogenic MEG, particularly in pediatric settings. Tune in as Dr. Feys takes us through his groundbreaking research and its potential implications for epilepsy treatment in children.

Keywords: Magnetoencephalography, Epilepsy, Pediatric Neurology, Dr. Feys, On-Scalp MEG, Optically Pumped Magnetometers, Interictal Epileptiform Discharges.

On-Scalp Optically Pumped Magnetometers versus Cryogenic Magnetoencephalography for Diagnostic Evaluation of Epilepsy in School-aged Children https://doi.org/10.1148/radiol.212453