Ongoing national and global cyberinfrastructure initiatives pose significant information organization challenges. Research targeting metadata helps address these challenges. This presentation covers a set of studies investigating technical, conceptual, and semantic-driven metadata solutions for organizing the deluge of digital data. The presentation introduces the Dryad data repository and the HIVE ontology environment; outlines motivating research questions and methods; and highlights key findings to date, noting the wider implications of this work. Further, I will describe new research emphases, including work as a Data Science Fellow at the National Consortium for Data Science, in affiliation with the Renaissance Computing Institute in Chapel Hill, North Carolina. I conclude by discussing how research focusing on metadata is an integral component of information organization and integrates with the I School environment.