What happens when AI agents can autonomously discover, execute, and chain genomic analyses using natural language? This episode introduces the concept of agentic genomics and explores how it is reshaping who can do genomics, how fast, and what questions they can ask. We examine the emerging ecosystem of agentic systems, the critical validation challenges they create, the equity implications of automating genomic analysis at scale, and a five-principle framework for responsible adoption. Based on a Perspective submitted to a leading genomics journal.