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Agentic Genomics: From Pipeline Automation to Autonomous Validation (SCGG Away Day, KCL)
Talk by Dr Manuel Corpas at the SCGG Away Day, King's College London, 15 April 2026.
Demonstrates agentic AI for genomic analysis using a family whole-genome sequencing case study, with a tiered validation framework (research-grade, cohort-grade, clinical-grade). Shows 100% rank concordance (20/20) against a 2022 peer-reviewed benchmark.
Topics covered:
- What agentic genomics means (runtime decisions vs fixed pipelines)
- KING-robust kinship verification on family WGS
- Polygenic risk scoring across 18 CAD PRS methods
- Agent failure modes and REF-aware scoring fix
- Tiered validation framework for agent-generated results
ClawBio: https://github.com/ClawBio/ClawBio
Docs: https://docs.clawbio.ai
Dr Manuel Corpas | Genomics, AI and Bioinformatics
University of Westminster
#genomics #bioinformatics #AI #agenticAI #PRS #polygenicrisk #ClawBio #personalgenomics #validation #KCL
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By Manuel CorpasTalk by Dr Manuel Corpas at the SCGG Away Day, King's College London, 15 April 2026.
Demonstrates agentic AI for genomic analysis using a family whole-genome sequencing case study, with a tiered validation framework (research-grade, cohort-grade, clinical-grade). Shows 100% rank concordance (20/20) against a 2022 peer-reviewed benchmark.
Topics covered:
- What agentic genomics means (runtime decisions vs fixed pipelines)
- KING-robust kinship verification on family WGS
- Polygenic risk scoring across 18 CAD PRS methods
- Agent failure modes and REF-aware scoring fix
- Tiered validation framework for agent-generated results
ClawBio: https://github.com/ClawBio/ClawBio
Docs: https://docs.clawbio.ai
Dr Manuel Corpas | Genomics, AI and Bioinformatics
University of Westminster
#genomics #bioinformatics #AI #agenticAI #PRS #polygenicrisk #ClawBio #personalgenomics #validation #KCL