Prepare for part one of a "Collision Course" against the Shrike. Sarge is now leading a team against the global threat, but he doesn't get to use his own people. Mack assigns Daisy and May to go with Sarge and Snowflake to stop the Shrike before the invasion begins. There is mistrust and tension between everyone though, so Mack follows in the Zephyr to keep an eye on the mysterious doppelganger. On the way, Sarge reveals that the real threat is Izel, who happens to be on her way to Earth with Fitz and Simmons. The three teams all approach the Shrike tower towards possible oblivion as Sarge arms the truck to blow up, with the team inside. Jay and Josh extort 10% of Deke's profits on this week's Agents of S.H.I.E.L.D.: Case Files.