This report from the International Social Security Association (ISSA) explores the use of artificial intelligence (AI) in social security organizations around the world. It examines the potential benefits of using AI, such as improving service delivery, automating tasks, and preventing fraud, while also considering the challenges, such as data quality, bias, and transparency. The report highlights the need for responsible and explainable AI, as well as for strong human capital to ensure that AI is used ethically and effectively. It also discusses the global uptake of AI and ongoing regulations, and provides a framework for assessing AI readiness in both national governments and social security institutions.