JAMA+ AI launches as a groundbreaking platform within the JAMA Network, aiming to integrate artificial intelligence into healthcare by bridging the gap between emerging technologies and the medical community. Led by Roy Perlis and Kirsten Bibbins-Domingo, the initiative offers diverse content, including studies and commentaries, to make AI accessible across medical specialties. As AI becomes more prevalent in healthcare, ethical considerations, regulatory frameworks, and collaboration among stakeholders are essential to ensure its responsible and effective implementation.