Brad and Mike discuss what would happen if humans went to war with aliens and lost. They explore different scenarios and movies where aliens attack Earth and humans prevail, but also consider the possibility of humans being wiped out by a more technologically advanced species. They reference movies like War of the Worlds, Independence Day, and Avatar, as well as books like The Expanse and The Hitchhiker's Guide to the Galaxy. They also touch on the idea of humans being observed by aliens without being attacked. The conversation ends with a mention of the upcoming release of the movie Alien Romulus.