Medizin - Open Access LMU - Teil 10/22

Alkalinization during re-oxygenation prevents functional damage by hyperglycaemic hypoxia


Listen Later

HYPERGLYCAEMIA impairs recovery from transient cerebral ischaemia: the importance of tissue acidification for this phenomenon has not been clarified in detail. We investigated this issue in a less complex in vitro preparation of isolated rat dorsal spinal roots exposed for 30 min to hyperglycaemic hypoxia. Peak height of compound action potentials recovered minimally in 5 mM bicarbonate. However, recovery was greatly improved by addition of the weak base trimethylamine during re-oxygenation. Addition of the weak acid propionate had no such effect. Cytoplasmic alkalinization improved recovery in a brief time window only: application of trimethylamine after 15 min of re-oxygenation was without beneficial effect. These data emphasize the importance of cytoplasmic acidification for neurophysiological recovery from hyper-glycaemic hypoxia during the initial period of re-oxygenation.
...more
View all episodesView all episodes
Download on the App Store

Medizin - Open Access LMU - Teil 10/22By Ludwig-Maximilians-Universität München


More shows like Medizin - Open Access LMU - Teil 10/22

View all
Einführung in die Ethnologie by Prof. Dr. Frank Heidemann

Einführung in die Ethnologie

0 Listeners

Theoretical Physics Schools (ASC) by The Arnold Sommerfeld Center for Theoretical Physics (ASC)

Theoretical Physics Schools (ASC)

2 Listeners

Chemie und Pharmazie - Open Access LMU - Teil 01/02 by Ludwig-Maximilians-Universität München

Chemie und Pharmazie - Open Access LMU - Teil 01/02

0 Listeners

MCMP – Mathematical Philosophy (Archive 2011/12) by MCMP Team

MCMP – Mathematical Philosophy (Archive 2011/12)

6 Listeners

Hegel lectures by Robert Brandom, LMU Munich by Robert Brandom, Axel Hutter

Hegel lectures by Robert Brandom, LMU Munich

6 Listeners

MCMP – Metaphysics and Philosophy of Language by MCMP Team

MCMP – Metaphysics and Philosophy of Language

2 Listeners

MCMP – Philosophy of Science by MCMP Team

MCMP – Philosophy of Science

1 Listeners

Sommerfeld Lecture Series (ASC) by The Arnold Sommerfeld Center for Theoretical Physics (ASC)

Sommerfeld Lecture Series (ASC)

0 Listeners

Medizin - Open Access LMU - Teil 12/22 by Ludwig-Maximilians-Universität München

Medizin - Open Access LMU - Teil 12/22

0 Listeners

Women Thinkers in Antiquity and the Middle Ages - SD by Peter Adamson

Women Thinkers in Antiquity and the Middle Ages - SD

0 Listeners