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ALT-FLOW II Trial: Shunting Innovation for HFpEF and Beyond with Dr. Firas Zahr and Dr. Andrei Pop
Can creating a shunt between the left atrium and the coronary sinus improve symptoms for patients with heart failure with preserved ejection fraction (HFpEF)?
In this in-depth discussion, Dr. Andrei Pop and Dr. Firas Zahr, PI of the ALT-FLOW II Trial, explore the science, physiology, and patient selection behind one of the most intriguing new frontiers in interventional heart failure.
Key takeaways:
What makes ALT-FLOW different from previous intra-atrial shunt devices
How shunt location, size, and flow patterns affect outcomes
Which heart failure patients respond best — HFpEF, HFrEF, or mixed phenotypes
Why resting wedge pressures don’t predict exercise hemodynamics
The importance of exercise right heart catheterization and PCWL measurement
Insights on stroke risk and why preserving the atrial septum may matter for lifetime procedures
How ALT-FLOW maintains procedural simplicity and safety through the coronary sinus approach
Expanding the field of interventional heart failure and device-based diastolic therapies
This conversation is essential for structural heart and heart failure specialists exploring new options for symptomatic HFpEF patients in the modern era of shunt-based therapy.
🔔 Subscribe for more insights from interventional experts and real-world program builders.
📱 Download the app: https://apps.apple.com/app/apple-store/id1586692687
📺 Follow us on YouTube: https://www.youtube.com/channel/UCfrLYhAhliQ2ZvXinkDCZvA
Chapters:
00:00 – Intro: The rise of interventional heart failure
00:45 – What makes the ALT-FLOW device unique
01:20 – Lessons learned from prior shunt trials
02:30 – Which patients may benefit most
04:00 – Persistent symptoms after valve repair and TAVR
05:00 – Stroke risk and shunt design safety
06:30 – Importance of preserving the interatrial septum
07:00 – Exercise right heart catheterization and PCWL
08:30 – What exercise reveals about true physiology
10:30 – When wedge pressures tell the real story
12:00 – Expanding tools for diastolic dysfunction
13:30 – Sham control and endpoint selection in ALT-FLOW II
15:30 – Heart failure specialists re-engaging with HFpEF
17:00 – Pacemaker leads and coronary sinus access
18:00 – Future of interventional heart failure
19:30 – Industry, innovation, and economics of device therapy
21:00 – Safety data and operator experience so far
23:00 – Future: Finding the right HFpEF subsets
24:30 – Closing reflections and next steps in research
#ALTFlow #HFpEF #HeartFailure #StructuralHeart #InterventionalCardiology #CoronarySinusShunt #HeartFailureDevice #CathLab #MurmurMD
View all episodes
By MurmurMDCan creating a shunt between the left atrium and the coronary sinus improve symptoms for patients with heart failure with preserved ejection fraction (HFpEF)?
In this in-depth discussion, Dr. Andrei Pop and Dr. Firas Zahr, PI of the ALT-FLOW II Trial, explore the science, physiology, and patient selection behind one of the most intriguing new frontiers in interventional heart failure.
Key takeaways:
What makes ALT-FLOW different from previous intra-atrial shunt devices
How shunt location, size, and flow patterns affect outcomes
Which heart failure patients respond best — HFpEF, HFrEF, or mixed phenotypes
Why resting wedge pressures don’t predict exercise hemodynamics
The importance of exercise right heart catheterization and PCWL measurement
Insights on stroke risk and why preserving the atrial septum may matter for lifetime procedures
How ALT-FLOW maintains procedural simplicity and safety through the coronary sinus approach
Expanding the field of interventional heart failure and device-based diastolic therapies
This conversation is essential for structural heart and heart failure specialists exploring new options for symptomatic HFpEF patients in the modern era of shunt-based therapy.
🔔 Subscribe for more insights from interventional experts and real-world program builders.
📱 Download the app: https://apps.apple.com/app/apple-store/id1586692687
📺 Follow us on YouTube: https://www.youtube.com/channel/UCfrLYhAhliQ2ZvXinkDCZvA
Chapters:
00:00 – Intro: The rise of interventional heart failure
00:45 – What makes the ALT-FLOW device unique
01:20 – Lessons learned from prior shunt trials
02:30 – Which patients may benefit most
04:00 – Persistent symptoms after valve repair and TAVR
05:00 – Stroke risk and shunt design safety
06:30 – Importance of preserving the interatrial septum
07:00 – Exercise right heart catheterization and PCWL
08:30 – What exercise reveals about true physiology
10:30 – When wedge pressures tell the real story
12:00 – Expanding tools for diastolic dysfunction
13:30 – Sham control and endpoint selection in ALT-FLOW II
15:30 – Heart failure specialists re-engaging with HFpEF
17:00 – Pacemaker leads and coronary sinus access
18:00 – Future of interventional heart failure
19:30 – Industry, innovation, and economics of device therapy
21:00 – Safety data and operator experience so far
23:00 – Future: Finding the right HFpEF subsets
24:30 – Closing reflections and next steps in research
#ALTFlow #HFpEF #HeartFailure #StructuralHeart #InterventionalCardiology #CoronarySinusShunt #HeartFailureDevice #CathLab #MurmurMD