Doctors once shied away from using opioids to treat chronic pain, citing the risk of addiction. But in the 1970s, a new generation of doctors started to argue that opioids should be reconsidered, and that allowing terminal patients to suffer in agony is torturous. As the palliative care movement grows, Purdue Frederick, a small pharmaceutical company, sees an opportunity to bring opioids out of the shadows and to the masses...to devastating effect.

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Today social media is such a dominant part of our daily lives, it's hard to believe that only 20 years ago, it didn’t exist. Then a newly single tech entrepreneur named Jonathan Abrams wondered: What if you could use the internet to expand your network of real-life friends? His simple idea became Friendster, the first social media site, which would change not only how people interact online, but the very nature of human connection and friendship.

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In the late 1970s, oil and natural gas fields across the U.S. were drying up, making the country increasingly dependent on foreign oil. Then, a Texas energy magnate named George Mitchell decided to try extracting natural gas from shale, a layer of rock almost two miles beneath the surface, using a technique called hydraulic fracturing, or fracking. His innovation would kick off an energy revolution, and spur a massive environmental backlash.

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Not everyone chooses burial or cremation after death. Some believe in cryonics, freezing their bodies in the hopes of being reanimated sometime in the future. Bob Nelson, a TV repairman with no scientific background, made history when he froze the first human being. But as Nelson would discover, freezing someone is easy; keeping them frozen is a lot harder.

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No extreme weather phenomenon fascinates us more than tornadoes. For most of human history, very little was known about how these graceful yet violent columns of swirling air formed or behaved. Then, in the 1950s, a teenager from North Dakota began chasing them, and a scientist from Japan began studying them. Together, they started a movement.

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Hackers: the criminals who prey on our digital lives. Today they steal credit cards and personal information, or even commit acts of cyber-terrorism. But in the early days, hackers were largely seen as harmless pranksters. And it wasn’t computers they were initially interested in, but phones -- which they hacked with a mysterious device called the Blue Box.

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In the 1940s, as planes got faster, it seemed like they were hitting a wall -- literally. Many pilots tried to travel faster than the speed of sound, often with fatal results. Could American test pilot Chuck Yeager succeed where they had failed? Or would his daredevil attitude get him grounded before he gets a chance?

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