WolverHeme Happy Hour

AML Maintenance Part 1: Set Your QUAZARs to Stun

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In the first of a two part-series, Anthony and Bernie dive into the data surrounding maintenance therapies in AML. This episode focuses on maintenance therapy for patients ineligible for transplant, with a focus on oral azacitidine and the controversial QUAZAR study.


Key References:

  • QUAZAR AML-001: https://pubmed.ncbi.nlm.nih.gov/33369355/
  • QUAZAR Letter to the Editor: https://pubmed.ncbi.nlm.nih.gov/33789022/
    • ASH Abstract Data on impact of # of Consolidation Cycles: https://ash.confex.com/ash/2020/webprogram/Paper138498.html
    • Hovon 97 (Azacitidine SQ maintenance): https://pubmed.ncbi.nlm.nih.gov/30630862/
      • Mayer, et al. NEJM. 1994. (CALGB HiDAC consolidation): https://pubmed.ncbi.nlm.nih.gov/8078551/
      • Büchner, et al. JCO. 1985: https://pubmed.ncbi.nlm.nih.gov/3906048/
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        WolverHeme Happy HourBy Bernard Marini, Anthony Perissinotti, et al.
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