In the fifth episode our special edition of the Ampersand Podcast, Mark Trodden, Dean of Penn Arts & Sciences and Thomas S. Gates, Jr. Professor of Physics & Astronomy, speaks with Bhuvnesh Jain, Walter H. and Leonore C. Annenberg Professor in the Natural Sciences and the Co-Director of the Penn Data Driven Discovery Initiative and the Penn Center for Particle Cosmology. The two discuss how advances in data science and artificial intelligence are transforming cosmology, teaching, and interdisciplinary research at Penn.