🎙️ Podcast Segment: Amyloidosis — PYQ Breakdown & Concept Mastery

❓ PYQ Example

Question: Which stain is used to identify amyloid deposits in tissue sections?

A. PAS

B. Congo red

C. Hematoxylin

D. Ziehl-Neelsen

✅ Correct Answer: B. Congo red

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🧠 Concept Breakdown

- Amyloidosis is a condition where misfolded proteins deposit extracellularly in tissues.

- These proteins form β-pleated sheets, giving them unique staining and birefringence properties.

- Types of Amyloid:

- AL (light chain) — seen in multiple myeloma

- AA (acute phase reactant) — seen in chronic inflammation

- Aβ — seen in Alzheimer’s disease

- Staining: Congo red stain shows apple-green birefringence under polarized light — a classic PYQ clue.

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⚠️ Caution for Students

- Don’t confuse PAS stain (used for glycogen) with Congo red for amyloid.

- Know the clinical associations — e.g., nephrotic syndrome, restrictive cardiomyopathy, macroglossia.

- Amyloid deposits are extracellular, not intracellular — a common MCQ trap.

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🩺 Clinical Relevance

- Systemic amyloidosis affects kidneys, heart, liver, and nerves.

- Localized amyloidosis includes Alzheimer’s and medullary thyroid carcinoma.

- Diagnosis involves biopsy + Congo red staining + clinical correlation.

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🎙️ Title

"Amyloidosis Uncovered: PYQ Mastery for NEET PG & FMGE"

📝 Description

This episode tackles one of the most conceptually tricky and frequently asked topics in NEET PG/FMGE/INICET — Amyloidosis. Learn the types, staining techniques, clinical relevance, and how to avoid common traps in under 10 minutes. Designed by a medico, for medicos.

NEETPG #FMGEprep #INICET #Amyloidosis #PathologyPYQ #MedicoPodcast #RapidReview #MedicalStudents #ExamPrep #MBBS #HighYieldPathology #SpotifyPodcast

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