In this fifteenth installment of the OFID podcast, Alysse Wurcel, MD, MS, shares her work in infectious complications of addiction with Editor Paul Sax, MD. She discusses her OFID article “Increasing Infectious Endocarditis Admissions Among Young People Who Inject Drugs,” as well as shares some of the challenges of coaching other health professionals when treating infection drug use and staying positive when entrenched in this often heavy work.