In this seventh installment of the Open Forum Infectious Diseases podcast, Editor in Chief Paul Sax, MD, interviews Angela Caliendo, MD, PhD, about the latest advances in the microbiology laboratory and where the future will lead as clinicians demand faster and more accurate pathogen diagnostics. The pair explores the implementation of MALDI-TOF mass spectometry in the U.S., the time it saves in the laboratory, and how it can help prevent the overuse of antibiotics.