In the ninth installment of the Open Forum Infectious Diseases podcast, Editor in Chief Paul Sax, MD, explores the current Zika virus outbreak with Duane Gubler, ScD, MS, who specializes in vector-borne infectious diseases. Dr. Gubler walks through the epidemiology of Zika and postulates both how Zika made its way to Brazil from the South Pacific and how this disease could impact the United States.