In this first of four episodes focusing on nonprofit publisher Annual Reviews and the ongoing evolution of the organization, Bill talks with Richard Gallagher, the President and Editor-in-Chief, about the organization’s history and how those first reviews came together. They also discuss what goes into a review, how the process has changed over the years, and they begin to look ahead to how opening up content at Annual Reviews—by making it freely available to read and reuse on the web—allows this vital synthesis of research in areas like Public Health to reach a wider audience and achieve greater societal impact.