Focused on perianal pathology, this episode establishes MRI as the gold standard for mapping complex fistulas (Likelihood Ratio 22.7). We review Heller's Rule for fistula risk and the four core principles of management, prioritizing sepsis control over repair. The discussion includes the contraindication of steroids in perianal disease, the use of loose setons, and emerging therapies like adipose-derived stem cells, while challenging the utility of traditional cutting repairs like LIFT in this population.