Antibiotic alternatives can promote growth, boost the immune system, and prevent intestinal diseases, thus improving gut health and function in poultry and swine. In this podcast, Drs. Martin Nyachoti and Chengbo Yang discuss with Amy Johnston the results of research they and others have conducted at the Department of Animal Science, University of Manitoba on various antibiotic alternatives. Although those in-feed antibiotic alternatives can help maintain a healthy gut in poultry and swine, the role of good nutritional strategies, and health and husbandry management practices are also discussed.