In this episode, we explore how a targeted approach to neurotransmitters such as serotonin, dopamine, and acetylcholine, can optimize antiemetic therapy. We break down key safety concerns for commonly used agents, including QT prolongation with ondansetron, extrapyramidal effects from metoclopramide and phenothiazines, and anticholinergic risks with diphenhydramine. Tune in for practical tips to balance efficacy and safety in managing nausea and vomiting across clinical settings.