Is antimicrobial resistance (AMR) the greatest threat to human health? In this episode, we discuss how the misuse and overuse of antimicrobials in humans and agriculture have accelerated bacteria, viruses, and other pathogens’ ability to mutate and develop resistance against the treatments designed to curb and control them. We talked with molecular biologist Stephen Baker, virologist Ian Goodfellow and infectious disease epidemiologist Caroline Trotter about the magnitude of the problem and how it is not a problem of the future, but of the now. Along the way, we discuss whether post COVID19, are we in a better position now to deal with the next pandemic? Can we predict when it might happen? And if it does happen, will we deal with it any differently?