Most cases of colorectal cancer are linked to mutational inactivation of the Adenomatous polyposis coli (APC) tumour suppressor. In this podcast Mariann Bienz discusses her Open Biology paper 'The Adenomatous polyposis coli tumour suppressor is essential for Axin complex assembly and function and opposes Axin's interaction with Dishevelled' and the role APC plays in the development of colorectal cancer.