Norman's Medical Review Podcast

APCM 2---HEMATOLOGY----Disseminated Intravascular Coagulation


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When there is severe bleeding regardless of the cause the clotting factors V and V111 , fibrinogen and platelets migrate to the site to form a plug . Most time these clotting factors are fully consumed with subsequent clot formation. As a result of these clot formation plasmin is released. Plasmin is designed to breakdown fibrinogen and prevent clots. As a result of fibrinogen being broken down by plasmin, platelet aggregation is inhibited, fibrin polymerization is inhibited and thrombin is inhibited. This leads to uncontrolled bleeding. So DIC starts with bleeding, consumption of clotting factors, micro clot formation, the release of plasmin and finally the inhibition of platelets, fibrin and thrombin with full blown hemorrhage as the end result.
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Norman's Medical Review PodcastBy Norman McCulloch PA-C | Keith Ko PA-C

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