In this insightful discussion, nurse practitioners HoChong Gilles and Sarah Dawkins explore the critical role of multidisciplinary care in the management of Primary Biliary Cholangitis (PBC). As a complex autoimmune liver disease, PBC often requires more than hepatology alone—patients benefit from a collaborative approach that includes endocrinology for bone health, primary care for fatigue evaluation, dermatology for refractory pruritus, mental health specialists, pharmacists, social workers, cardiology, rheumatology, and registered dietitians. Gilles and Dawkins emphasize how coordinated care improves quality of life, supports symptom management, and addresses barriers to access such as medication affordability and social determinants of health. They also highlight the importance of patient advocacy groups and holistic strategies like exercise and nutritional support. This video is essential viewing for clinicians seeking to elevate outcomes and deliver patient-centered, team-based care for individuals living with chronic liver disease.