This episode explores the critical topic of infections in older adults, drawing directly from the detailed insights provided by UpToDate. It covers why older adults are more susceptible to infections due to age-related physiological and immunological changes, as well as societal factors. The podcast highlights atypical presentations, modified fever definitions, and the need for a lower threshold of suspicion in this population. It also delves into antibiotic management, addressing altered pharmacokinetics, the risk of multidrug-resistant organisms, and the importance of antibiotic stewardship. Specific infectious syndromes like UTIs and pneumonia are discussed, along with immunization and travel considerations. Each subtopic concludes with the memorable phrase, “if you can’t remember everything, remember this,” ensuring residents retain the most critical points for effective patient care.