In this month's Cell Podcast, we learn about how cells sense when they're feeling sluggish and need to refuel, with Claudio De Virgilio (0:00) (Bonfils et al. and Han et al.), a eureka moment in the lab becomes a new therapy in the clinic, with Laurie Glimcher (7:16) (Cell Special Issue on Human Diseases), and a shape-shifting enzyme busts blood clots, with James Whisstock (14:12) (Law et al.). Plus, sample a selection of the hottest new papers from Cell Press (22:25).