JACI: In Practice Deputy Editor Scott Sicherer describes the April issue, the theme of which is “Difficult Decisions in Food Allergy”. Theme topics covered include precautionary allergen labeling, oral food challenges, immunotherapy, and epinephrine treatment. Dr. Sicherer then presents the Highlights of the Original Articles in the issue, which are on the topics of Food Allergy, Anaphylaxis, Asthma, Drug Allergy, Hereditary Angioedema, Immunodeficiency, Rhinitis, and Urticaria.