In this April episode of the Transplant International Podcast, Deputy Editor-in-Chief Nina Pilat, Co-host Antonio Citro, and Editorial Fellow Andrea Zajacova explore three major highlights from the current issue. First, they discuss the new ESOT position paper providing a comprehensive strategic framework for responsible and high-quality AI adoption in transplantation. Next, they delve into a review detailing the logistical and therapeutic paradigm shift towards multi-day solid organ and tissue perfusion. Finally, they review original research uncovering the active proinflammatory role of cell-free DNA (cfDNA) as a damage-associated molecular pattern in liver ischemia-reperfusion injury.