In this episode, we review the recently published ARISE-Fluids trial, which compared a restrictive fluid strategy with early vasopressor use against a more liberal fluid approach with delayed vasopressors. We place the trial in context, discuss the prior evidence, and unpack the key findings. We also use the study as a springboard to introduce “time-to-event” outcomes, before reflecting on the trial’s strengths and limitations.

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You can also explore our methods blog at: ccmevidence.blog