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¿Artralgia o Artritis?
¡Gracias por escuchar! Los pacientes con artralgia clínicamente sospechosa tienen síntomas articulares como dolor y rigidez de las articulaciones pequeñas sin signos clínicos de artritis. Algunos de estos pacientes progresan y desarrollan una enfermedad 'verdadera', pero ¿cómo podemos diferenciar la enfermedad crónica en evolución de la enfermedad que se resolverá? En este episodio se comentará un estudio reciente que pretende ayudar con la respuesta a esta pregunta.
Estas son algunas referencias de utilidad:
Al-Laith, M. et al. Arthritis prevention in the pre-clinical phase of RA with abatacept (the APIPPRA study): a multi-centre, randomised, double-blind, parallel-group, placebo-controlled clinical trial protocol. Trials 20, 429 (2019).
Brulhart, L. et al. Ultrasound is not associated withthe presence of systemic autoimmunity or symptoms in individuals at risk for rheumatoid arthritis. RMD Open. 5, e000922 (2019).
Gerlag, D. M. et al. Effects of B cell directed therapy on the preclinical stage of rheumatoid arthritis: the PRAIRI study. Ann. Rheum. Dis. 78, 179–185 (2019).
Kleyer, A. et al. High prevalence of tenosynovial inflammation before onset of rheumatoid arthritis and its link to progression to RA-A combined MRI/CT study. Semin. Arthritis Rheum. 46, 143–150 (2016).
Kleyer, A. et al. Bone loss before the clinical onset of rheumatoid arthritis in subjects with anticitrullinated protein antibodies. Ann. Rheum. Dis. 73, 854–860 (2014).
Raza, K. et al. Early rheumatoid arthritis is characterized by a distinct and transient synovial fluid cytokine profile of T cell and stromal cell origin. Arthritis Res. Ther. 7, R784–R795 (2005).
Sahbudin, I. et al. The role of ultrasound-defined tenosynovitis and synovitis in the prediction of rheumatoid arthritis development. Rheumatology (Oxford). 57, 1243–1252 (2018).
ten Brinck, R. M. et al. Improvement of symptoms in clinically suspect arthralgia and resolution of subclinical joint inflammation: a longitudinal study in patients that did not progress to clinical arthritis. Arthritis Res. Ther. 22, 11 (2020).
van Steenbergen, H. W. et al. EULAR definition of arthralgia suspicious for progression to rheumatoid arthritis. Ann. Rheum. Dis. 76, 491–496 (2017).
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By Daniel Xibille Friedmann¡Gracias por escuchar! Los pacientes con artralgia clínicamente sospechosa tienen síntomas articulares como dolor y rigidez de las articulaciones pequeñas sin signos clínicos de artritis. Algunos de estos pacientes progresan y desarrollan una enfermedad 'verdadera', pero ¿cómo podemos diferenciar la enfermedad crónica en evolución de la enfermedad que se resolverá? En este episodio se comentará un estudio reciente que pretende ayudar con la respuesta a esta pregunta.
Estas son algunas referencias de utilidad:
Al-Laith, M. et al. Arthritis prevention in the pre-clinical phase of RA with abatacept (the APIPPRA study): a multi-centre, randomised, double-blind, parallel-group, placebo-controlled clinical trial protocol. Trials 20, 429 (2019).
Brulhart, L. et al. Ultrasound is not associated withthe presence of systemic autoimmunity or symptoms in individuals at risk for rheumatoid arthritis. RMD Open. 5, e000922 (2019).
Gerlag, D. M. et al. Effects of B cell directed therapy on the preclinical stage of rheumatoid arthritis: the PRAIRI study. Ann. Rheum. Dis. 78, 179–185 (2019).
Kleyer, A. et al. High prevalence of tenosynovial inflammation before onset of rheumatoid arthritis and its link to progression to RA-A combined MRI/CT study. Semin. Arthritis Rheum. 46, 143–150 (2016).
Kleyer, A. et al. Bone loss before the clinical onset of rheumatoid arthritis in subjects with anticitrullinated protein antibodies. Ann. Rheum. Dis. 73, 854–860 (2014).
Raza, K. et al. Early rheumatoid arthritis is characterized by a distinct and transient synovial fluid cytokine profile of T cell and stromal cell origin. Arthritis Res. Ther. 7, R784–R795 (2005).
Sahbudin, I. et al. The role of ultrasound-defined tenosynovitis and synovitis in the prediction of rheumatoid arthritis development. Rheumatology (Oxford). 57, 1243–1252 (2018).
ten Brinck, R. M. et al. Improvement of symptoms in clinically suspect arthralgia and resolution of subclinical joint inflammation: a longitudinal study in patients that did not progress to clinical arthritis. Arthritis Res. Ther. 22, 11 (2020).
van Steenbergen, H. W. et al. EULAR definition of arthralgia suspicious for progression to rheumatoid arthritis. Ann. Rheum. Dis. 76, 491–496 (2017).