In this episode, we dive into the PREVENT CLOT trial, which compared aspirin to low-molecular-weight heparin (LMWH) for thromboprophylaxis in orthopedic trauma. While the study found aspirin to be noninferior in preventing all-cause mortality, some clinicians raise concerns about its limited generalizability. We break down the findings, the controversy, and what it all means for real-world practice, especially in higher-risk patients. Tune in for a balanced look at evidence-based prophylaxis and the importance of individualized care.