Measuring vancomycin levels has long been an important component of laboratory therapeutic drug monitoring. Such measurements are important for obtaining optimal targets serum concentrations for drug dosing, while avoiding vancomycin induced nephrotoxicity. "AUC-Based Monitoring of Vancomycin: Closing the Therapeutic Window" was published in the January 2019 issue of The Journal of Applied Laboratory Medicine. This review evaluates shifting the conventional therapeutic drug monitoring approach of vancomycin from trough monitoring, to an area under the curve approach for more appropriate drug dosing.