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Ayahuasca: The Vine of Souls explores the long and complex history of one of the Amazon’s most mysterious ceremonial brews. From ancient Indigenous knowledge systems and rainforest ecology to colonial disruption, modern science, and global tourism, the episode traces how ayahuasca evolved from a sacred Amazonian practice into an international subject of fascination and debate. Along the way, it examines the deep relationship between humans, plants, ritual, and knowledge—and asks a haunting question that history still cannot fully answer: how was this remarkable combination of plants discovered in the first place? 

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