Link to bioRxiv paper:

http://biorxiv.org/cgi/content/short/2020.07.25.192310v1?rss=1

Authors: Altan-Bonnet, N., Altan-Bonnet, G. Y., Ghosh, S., Dellibovi-Ragheb, T., Pak, E., Qiu, Q., Fisher, M., Takvorian, P., Bleck, C., Hsu, V., Fehr, A., Perlman, S., Straus, M., Whittaker, G., de Haan, C. A.

Abstract:

{beta}-Coronaviruses are a family of positive-strand enveloped RNA viruses that include the severe acute respiratory syndrome-CoV2 (SARS-CoV2). While much is known regarding their cellular entry and replication pathways, their mode of egress remains uncertain; however, this is assumed to be via the biosynthetic secretory pathway by analogy to other enveloped viruses. Using imaging methodologies in combination with virus-specific reporters, we demonstrate that {beta}-Coronaviruses utilize lysosomal trafficking for egress from cells. This pathway is regulated by the Arf-like small GTPase Arl8b; thus, virus egress is insensitive to inhibitors of the biosynthetic secretory pathway. Coronavirus infection results in lysosome deacidification, inactivation of lysosomal degradation and disruption of antigen presentation pathways. This coronavirus-induced exploitation of lysosomes provides insights into the cellular and immunological abnormalities observed in patients and suggests new therapeutic modalities.

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