Encore edition: What happens when antibiotics stop working? With drug-resistant infections on the rise, scientists are scrambling to develop new weapons in the fight against evolved bacteria-from cutting-edge diagnostic tests to revolutionary gene-editing techniques. Programming note: All new episodes resume in early September.

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Ultrasound is known for its use in imaging during pregnancy. But new advancements in the technology suggest that in the future, ultrasound  could be used to disrupt the blood-brain barrier. This would allow doctors to more easily diagnose and directly treat illnesses like brain cancer without major surgery. WSJ’s Danny Lewis and Charlotte Gartenberg examine the new ways that ultrasound could be used more specifically and subtly to deliver accurate diagnoses and precise treatments.



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Further reading:



New Ultrasound Therapy Could Help Treat Alzheimer’s, Cancer 

Treatment Breakthrough for an Intractable Brain Cancer 

The ‘Mini Brains’ solving medical mysteries and raising concerns

We Can Now See the Brain Like Never Before 

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Ultrasound Isn’t Just for Pregnancy. How It’s Helping Treat the Brain.

A day when people can interact directly with computers using their thoughts could be on the horizon. Several companies, including Elon Musk’s Neuralink, have begun preliminary human trials of brain-computer interfaces - devices that decode the electrical signals in their brain and translate them into digital bits. Neurosurgeon Benjamin Rapoport is a co-founder and chief science officer of Precision Neuroscience, a company working on brain-computer interfaces. He spoke with WSJ’s Danny Lewis about how the technology works and how these implants could improve the lives of hundreds of thousands of people who could gain the ability to independently engage with the digital world.



Correction: Dr. Benjamin Rapoport is the co-founder of Precision Neuroscience. An earlier version misspelled his name Rapaport. (Corrected on May 3)



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Further reading: 

Inside the Operating Room: Doctors Test a Revolutionary Brain-Computer Implant 

Elon Musk’s Neuralink Wants to Make ‘The Matrix’ a Reality. It Has a Lot to Prove First. 

She Didn’t Speak for 18 Years. A Computer Helped Find Her Voice. 

The Devices That Will Read Your Brain—and Enhance It 



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Chip in the Brain? How Brain-Computer Interfaces Could Change Medicine

What does the brick and mortar bookstore of the future look like? For Barnes & Noble, it looks more like the indie bookstores they once threatened to put out of business 20 years ago. The company recently redesigned their national chain of over 500 bookstores, shedding the big box personality in favor of a look reminiscent of local bookshops. On this week’s Science of Success, WSJ columnist Ben Cohen speaks to Barnes & Noble CEO James Daunt about the look, feel and idea behind Barnes & Noble’s new indie design.



What do you think about the show? Let us know on Apple Podcasts or Spotify, or email us: FOEPodcast@wsj.com 



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Further reading:

That Cool New Bookstore? It’s a Barnes & Noble.

New CEO Wants to Make Barnes & Noble Your Local Bookstore

Barnes & Noble’s New Boss Tries to Save the Chain—and Traditional Bookselling 

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Science of Success: How Barnes & Noble Is Redesigning the Bookstore Chain

Can technology help us design the perfect running shoe that’s stronger, faster and better for the environment? David Allemann, co-founder of On, thinks technology can get us part of the way there, but it’s not the whole story. The performance running shoe and sportswear company is experimenting with computer simulation and bio-based materials to design sneakers to advance both runners and sustainability goals. WSJ men’s fashion columnist Jacob Gallagher speaks with Allemann about the future of running shoe tech and how sneakers might redefine the design cannon. 



What do you think about the show? Let us know on Apple Podcasts or Spotify, or email us: FOEPodcast@wsj.com 



Further reading: 

How On’s Running Sneakers Won Over Tech Bros and High Fashion Alike 

Where Did All the Crazy Sneakers Go? 

This Designer Knows What Sneakers You’ll Be Wearing Next Year 

These Grandpa Sneakers Are Made in America. They’re a Hit Overseas. 

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Designing the Sneaker of the Future

3D printing isn’t just for hobbyists – it could be central to the future of manufacturing. Companies are turning to this technology to make everything from car and airplane parts to houses faster and cheaper than with traditional techniques. Now, as 3D printing – also known as additive manufacturing – is getting quicker, researchers are testing its limits. WSJ’s Alex Ossola and Danny Lewis take a look at how this tech is building the factory of the future.



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Further reading: 

This 3-D Printed Icelandic Fish-Gutting Machine Contains the Secret of a Future, Less-Globalized Economy 

Venture Investors Are Pumping Capital Into 3-D Printing Startups. Here’s Why. 

Energy Companies Turn to 3-D Printing to Bypass Snarled Supply Chains 

3-D Printed Houses Are Sprouting Near Austin as Demand for Homes Grows 



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Battling the Superbugs

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