"Be an A Major in a World Of C Majors" is depicting the fact that we humans should be ourselves and not adapt to the world and not be what it wants us to be. We must shine bright and be the radiant star that we were born to be and not chameleon our way in life but stand out. More importantly "put a lil' me in it", meaning that we should put a little bit of ourselves in everything that we set out to do.