The sermon emphasizes humility and fear of the Lord as the foundation for a blessed life, cautioning against self-sufficiency and pride which ultimately lead to disappointment. Drawing from Proverbs 3, it highlights the importance of departing from evil and seeking God's guidance rather than relying on personal wisdom, advocating for a posture of lowliness and obedience in all aspects of life, including work, relationships, and personal desires, ultimately leading to spiritual and physical well-being and a deeper understanding of God's will.