Thrombotic thrombocytopenic purpura (TTP) is one of the most urgent diagnoses in hematology where every minute counts and laboratory data is critical. In this episode, experts Long Zheng and Ravi Sarode discuss the critical role of the laboratory in diagnosing and managing TTP, with a special focus on the complexities of ADAMTS13 testing. Together, they unpack the latest ISTH guideline updates, compare current testing approaches and share practical strategies to improve collaboration between clinicians and laboratory teams. Learn more at www.isth.org/page/ttpguidelines.