Join Julia Mayerle and Francisco X. Real (Paco) as they reflect on the first-ever Digestive Disease Mechanism (DDM) Summit, introduced during UEG Week 2025 in Berlin.

In this special episode, they discuss how the DDM Summit brought together leading scientists and clinicians to explore the mechanisms driving GI cancers — from colorectal to pancreatic and liver cancer. Hear how cutting-edge discoveries in genomics, metabolism, and tumour microenvironment are already shaping translational research and clinical trials.

Julia and Paco also share highlights from the meeting, including exciting poster sessions, emerging collaborations, and their vision for the next DDM Summit focusing on inflammation in GI disease.

- 08:00 The evolution of colitis-associated colorectal cancer Trevor A. Graham (United Kingdom)

- 09:45 Tumour cell plasticity and immune evasion in metastatic colorectal cancer. Eduard Batlle Gomez (Spain)

- 11:45 Cutting the nerve supply to pancreatic cancer Andreas Trumpp (Germany)

- 16:40 Neutrophil-driven inflammation in PDAC progression Dieter Saur (Germany)

- 17:30 Exploring the therapy-associated tumour immune microenvironment across the spectrum of HCC Tom Bird (UK)

- 17:45 Intermittent fasting in MASH and liver cancer Suchira Gallage (Germany)

- 17:50 Metabolic drivers of cancer and obesity-related diseases Guadalupe Sabio (Spain)